![]() In previous studies, IPC has been proved to be effective for bone fracture healing by enhancing osteogenesis and vascularization. With evidence that IPC can enhance bone fractures with good functional recovery, IPC has been approved for clinical treatment on delayed union or nonunion bone fractures. Therefore, an increase in arterial blood flow to the fracture site may improve healing. Blood circulation is recognized as an important factor in fracture-healing. Meanwhile, the plasminogen activator inhibitor decreased. IPC cyclic compression on blood vessels leads to the increase of the synthesis of nitric oxide, prostacyclin, and tissue plasminogen activator. Cyclic pressure of IPC on muscles and blood vessels can decrease the venous stasis and increase the arterial blood flow. IPC can provide the cyclic positive and negative pressure and improve the arterial circulation. Physicians have tried to improve circulation by exerting external pressure on the arms and legs since nineteenth century. Intermittent pneumatic compression (IPC) is a special technique that has been mainly used in orthopedic practice to decrease the risk of deep vein thrombosis (DVT) and to reduce post-traumatic and post-operative swelling in various clinical situations. This has led to the introduction of several treatment modalities to enhance healing and expedite recovery. The intermittent pneumatic soft-tissue compression can accelerate new bone formation of bone defects and the optimal intensity is 8–10 kPa for repairing the rabbit radial bone defect.īone defect treatment aims to achieve osteogenesis and vascularization as soon as possible. The result of histology had shown that the trabeculae in bone callus in group C had a regular form, the trabeculae were wide and had a more become osteoblast around them. ![]() Fluorescent labeling results showed the speed of new bone formation in Group C was faster than that in other groups, among which the control group had the slowest speed of new bone formation. The Micro-CT results showed more new bony callus, bone trabecula and higher bone mineral density in group C. There was more new bony callus in the bone defect in group C than in other groups by gross observation and X-ray radiography at 2 and 4 weeks. New bone formation in 4 groups was evaluated by gross observation, X-ray, Micro-CT, and histological staining at 2 and 4 weeks after surgery. The stimulation lasted 30 min every day and the frequency of compression was 15 Hz. On the fourth day after surgery, their legs were intermittently pneumatic compressed for 4 weeks. Methodsįive mm radial bone defect in length was made in 64 mature New Zealand rabbits and all animals randomly assigned into four groups: Group A (control group without compression), Group B (5–7 kPa intensity), Group C (8–10 kPa intensity) and Group D (11–13 kPa intensity). To estimate the effects of different intensities of intermittent pneumatic soft-tissue compression on bone defect repair in an animal model.
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